The Irani score has been established as a measurement scale to categorize inflammation based on precise morphological criteria.1 The Irani inflammation score is a method that provides valuable insights into the inflammatory state of the prostate.2 By establishing a relationship between the morphological characteristics of inflammation and PSA levels, this score enriches the clinical analysis of BPH and may influence the global management of patients.1 The Irani is the standard for classifying all categories of inflammation.2
Inflammation and aggressiveness scales1
The scoring system is divided into two distinct scales: the inflammation scale and the aggressiveness scale.
- Inflammation: This scale ranges from 0 to 3, where '0' signifies no inflammatory cells, and '3' indicates large inflammatory areas with the confluence of infiltrate. The intermediate scores of '1' and '2' represent increasing degrees of inflammatory cell infiltration and lymphoid nodule formation.
- Aggressiveness: This scale measures the impact of inflammation on the glandular epithelial tissue. A score of '0' means no contact between the inflammatory cells and glandular epithelium, whereas a score of '3' indicates a disruption of glandular epithelium in more than 25% of the examined material.
Clinical significance of scores2
Scores from 0 to 2 are generally interpreted as minimal to moderate inflammation, while scores from 3 to 6 indicate moderate to severe inflammation.
The Irani score is particularly useful in classifying categories of prostatic inflammation. It standardizes the assessment of inflammation, which can aid in the interpretation of prostate biopsies and in clinical decision-making.