This is an international website dedicated to HealthCare Professionals (outside the UK, ROI and the US) for educational purposes. Please note that it has not been validated for and is not intended for clinical and diagnostic use.

The main benefit of this nomogram is to provide informative support to urologists seeking to identify men with LUTS who requires special attention, related to benign prostatic hyperplasia (BPH) and prostatic inflammation.1

Objectives and methodology1

The primary objective of PINS was to develop and validate a nomogram based on demographic and clinical characteristics to assess a likelihood of prostatic inflammation in men suffering from LUTS. This prospective, multicenter, non-interventional study included 423 men over 40 years, with an average age of 68.9 years, scheduled for prostatic surgery or transrectal ultrasound-guided prostatic biopsy across six centers in Southern Europe.

Key findings1

Analysis revealed several factors significantly associated with moderate to severe prostatic inflammation, including a prostate volume greater than 50 mL, a history of urinary tract infections, the presence of diabetes, the presence of leucocytes in urine, and a high IPSS storage score. The developed nomogram, based on these factors, demonstrated a good discriminatory ability with a concordance index of 0.71.

Implications1

The nomogram developed PINS has the potential to provide to clinicians valuable insights onto prostatic inflammation.

For detailed insights and more on the methodologies applied in this study, please refer to the full publication, Professor Stavros Gravas' “Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms”.

1. Gravas S, et al. Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms. Prostate Cancer Prostatic Dis. 2024 Jul 6. doi: 10.1038/s41391-024-00857-5. Epub ahead of print. PMID: 38971935.

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